Endocrine Abstracts

Objective: To examine the relationship between C-peptide levels and endogenous insulin secretion and to understand the effects of elevated C-peptide after dosing on evaluating study insulin and its analogs’ PK/PD values in euglycemic clamps.Method: The study included 33 healthy male volunteers who underwent an 8-h euglycemic clamp with a subcutaneous injection of insulin aspart (0.2 U/kg). Blood glucose (BG), C-peptide, human insulin, and insu...

Objective: Studies have demonstrated that patients with acromegaly have compromised bone health and an increased risk of vertebral fractures (VFs). However, the prevalence of VFs in Chinese patients with acromegaly has not been investigated by far. This study aimed to evaluate the prevalence and determinants of VFs in patients with acromegaly in a tertiary hospital in China.Methods: We enrolled patients diagnosed with acromegaly consecutively at West Chi...

Objective: To summarise and analyze the pathogenesis, clinical risk assessment, and treatment of venous thromboembolic events (VTE) associated with Cushing syndrome (CS), and to improve clinicians’ understanding of this complication.Methods: The clinical diagnosis and treatment of 3 patients with Cushing disease (CD) combined with pulmonary embolism were reviewed, and relevant literature at home and abroad was reviewed.Results...